The Siren's Kiss tells the story of three sisters, Mona (Jennie Garth), Rye (Cynthia Gibb), and Iona (Marilyn Manson), who are Sirens. They live in a remote coastal town, where they encounter a young man named Antony (Jeremy London). As the story unfolds, the Sirens' lives become intertwined with Antony's, leading to a tragic confrontation.