"You Know I'm No Good" has had a lasting impact on contemporary music, influencing a generation of artists across genres. The song's blend of soul, jazz, and R&B has been cited as an inspiration by artists such as Adele, Sam Smith, and Lana Del Rey, among others. Moreover, Winehouse's unflinching portrayal of vulnerability and regret has helped normalize conversations around mental health, relationships, and the complexities of human emotion.